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		<title>Mouthwashes, oral rinses may inactivate human coronaviruses</title>
		<link>https://ambatechllc.com/mouthwashes-oral-rinses-may-inactivate-human-coronaviruses/</link>
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		<pubDate>Wed, 21 Oct 2020 08:34:35 +0000</pubDate>
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					<description><![CDATA[<p>Mouthwashes, oral rinses may inactivate human coronaviruses Penn State College of Medicine researchers say certain oral antiseptics and mouthwashes may have the ability to inactivate human coronaviruses. They say clinical trials needed to determine if these products can reduce the amount of virus COVID-19 positive patients spread when talking, sneezing or coughing.  IMAGE: GETTY IMAGES [...]</p>
<p>The post <a href="https://ambatechllc.com/mouthwashes-oral-rinses-may-inactivate-human-coronaviruses/">Mouthwashes, oral rinses may inactivate human coronaviruses</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
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<h1>Mouthwashes, oral rinses may inactivate human coronaviruses</h1>
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<p>Penn State College of Medicine researchers say certain oral antiseptics and mouthwashes may have the ability to inactivate human coronaviruses. They say clinical trials needed to determine if these products can reduce the amount of virus COVID-19 positive patients spread when talking, sneezing or coughing.</p>
<p><span class="caption"> </span><span class="credit">IMAGE: GETTY IMAGES | JAE YOUNG JU</span></p>
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<div class="published-at">October 19, 2020</div>
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<p>HERSHEY, Pa. — Certain oral antiseptics and mouthwashes may have the ability to inactivate human coronaviruses, according to a <a href="https://med.psu.edu/">Penn State College of Medicine</a> research study. The results indicate that some of these products might be useful for reducing the viral load, or amount of virus, in the mouth after infection and may help to reduce the spread of SARS-CoV-2, the coronavirus that causes COVID-19.</p>
<p><a href="https://pennstate.pure.elsevier.com/en/persons/craig-meyers">Craig Meyers</a>, distinguished professor of microbiology and immunology and obstetrics and gynecology, led a group of physicians and scientists who tested several oral and nasopharyngeal rinses in a laboratory setting for their ability to inactivate human coronaviruses, which are similar in structure to SARS-CoV-2. The products evaluated include a 1% solution of baby shampoo, a neti pot, peroxide sore-mouth cleansers, and mouthwashes.</p>
<p>The researchers found that several of the nasal and oral rinses had a strong ability to neutralize human coronavirus, which suggests that these products may have the potential to reduce the amount of virus spread by people who are COVID-19-positive.</p>
<p>“While we wait for a vaccine to be developed, methods to reduce transmission are needed,” Meyers said. “The products we tested are readily available and often already part of people’s daily routines.”</p>
<p>Meyers and colleagues used a test to replicate the interaction of the virus in the nasal and oral cavities with the rinses and mouthwashes. Nasal and oral cavities are major points of entry and transmission for human coronaviruses. They treated solutions containing a strain of human coronavirus, which served as a readily available and genetically similar alternative for SARS-CoV-2, with the baby shampoo solutions, various peroxide antiseptic rinses and various brands of mouthwash. They allowed the solutions to interact with the virus for 30 seconds, one minute and two minutes, before diluting the solutions to prevent further virus inactivation. According to Meyers, the outer envelopes of the human coronavirus tested and SARS-CoV-2 are genetically similar so the research team hypothesizes that a similar amount of SARS-CoV-2 may be inactivated upon exposure to the solution.</p>
<p>To measure how much virus was inactivated, the researchers placed the diluted solutions in contact with cultured human cells. They counted how many cells remained alive after a few days of exposure to the viral solution and used that number to calculate the amount of human coronavirus that was inactivated as a result of exposure to the mouthwash or oral rinse that was tested. The <a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.26514">results</a> were published in the Journal of Medical Virology.</p>
<p>The 1% baby shampoo solution, which is often used by head and neck doctors to rinse the sinuses, inactivated greater than 99.9% of human coronavirus after a two-minute contact time. Several of the mouthwash and gargle products also were effective at inactivating the infectious virus. Many inactivated greater than 99.9% of virus after only 30 seconds of contact time and some inactivated 99.99% of the virus after 30 seconds.</p>
<p>According to Meyers, the results with mouthwashes are promising and add to the findings of a <a href="https://academic.oup.com/jid/article/222/8/1289/5878067">study</a> showing that certain types of oral rinses could inactivate SARS-CoV-2 in similar experimental conditions. In addition to evaluating the solutions at longer contact times, they studied over-the-counter products and nasal rinses that were not evaluated in the other study. Meyers said the next step to expand upon these results is to design and conduct clinical trials that evaluate whether products like mouthwashes can effectively reduce viral load in COVID-19-positive patients.</p>
<p>“People who test positive for COVID-19 and return home to quarantine may possibly transmit the virus to those they live with,” said Meyers, a researcher at Penn State Cancer Institute. “Certain professions including dentists and other health care workers are at a constant risk of exposure. Clinical trials are needed to determine if these products can reduce the amount of virus COVID-positive patients or those with high-risk occupations may spread while talking, coughing or sneezing. Even if the use of these solutions could reduce transmission by 50%, it would have a major impact.”</p>
<p>Future studies may include a continued investigation of products that inactive human coronaviruses and what specific ingredients in the solutions tested inactivate the virus.</p>
<p>Janice Milici, Samina Alam, David Quillen, David Goldenberg and Rena Kass of Penn State College of Medicine and Richard Robison of Brigham Young University also contributed to this research.</p>
<p>The research was supported by funds from Penn State Huck Institutes for the Life Sciences. The researchers declare no conflict of interest.</p>
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<div class="last-updated">Last Updated October 19, 2020</div>
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<p>The post <a href="https://ambatechllc.com/mouthwashes-oral-rinses-may-inactivate-human-coronaviruses/">Mouthwashes, oral rinses may inactivate human coronaviruses</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
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		<post-id xmlns="com-wordpress:feed-additions:1">2842</post-id>	</item>
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		<title>First human trial of SARS-CoV-2 vaccine: Initial results in</title>
		<link>https://ambatechllc.com/first-human-trial-of-sars-cov-2-vaccine-initial-results-in/</link>
		
		<dc:creator><![CDATA[ambalsoft]]></dc:creator>
		<pubDate>Thu, 28 May 2020 17:35:58 +0000</pubDate>
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					<description><![CDATA[<p>First human trial of SARS-CoV-2 vaccine: Initial results in Researchers from China report the initial findings of the first human trial for a potential vaccine against SARS-CoV-2, the new coronavirus. The results are promising, suggesting that the vaccine is mostly safe and apparently effective. The initial results of the first human trial for a SARS-CoV-2 [...]</p>
<p>The post <a href="https://ambatechllc.com/first-human-trial-of-sars-cov-2-vaccine-initial-results-in/">First human trial of SARS-CoV-2 vaccine: Initial results in</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
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										<content:encoded><![CDATA[<h1>First human trial of SARS-CoV-2 vaccine: Initial results in</h1>
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<p class="css-dmtxcr">Researchers from China report the initial findings of the first human trial for a potential vaccine against SARS-CoV-2, the new coronavirus. The results are promising, suggesting that the vaccine is mostly safe and apparently effective.</p>
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<figure class="css-1ewspfy"><span class="css-rwmw5v"><span class="css-rlaxw5"><picture class="css-16pk1is"><source srcset="//i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/05/GettyImages-556421531-1024x768.jpg?w=1575 750w" media="(min-width: 1190px)" /><source srcset="//i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/05/GettyImages-556421531-1024x768.jpg?w=1575 750w" media="(min-width: 990px)" /><source srcset="//i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/05/GettyImages-556421531-1024x768.jpg?w=1845 879w" media="(min-width: 768px)" /><img decoding="async" class="css-1lwg88w" src="https://i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/05/GettyImages-556421531-1024x768.jpg?w=1155&amp;h=4032" alt="gloved hands handling vaccine" /></picture></span></span><figcaption class="css-1h1noa3">The initial results of the first human trial for a SARS-CoV-2 vaccine are encouraging, say researchers.</figcaption></figure>
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<p>At present, there are numerous clinical trials around the world testing potential vaccines against the new coronavirus, <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/7543">SARS</a>-CoV-2.</p>
<p>The first human trial for such a vaccine <a class="content-link css-29oowu" href="https://www.reuters.com/article/brief-cansino-biologics-says-co-institut/brief-cansino-biologics-says-co-institute-of-biotechnology-academy-of-military-medical-sciences-jointly-developing-recombinant-novel-coronavirus-vaccine-idUSFWN2B9230" target="_blank" rel="noopener noreferrer">started in early March</a>. It is the work of researchers from several Chinese institutions, including the China National Institute for Food and Drug Control in Beijing, the Beijing Institute of Biotechnology, and the Chinese vaccine company CanSino Biologics.</p>
<p><a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/278779#phases">Phase 1</a> of this trial, which tests primarily for safety, has recently concluded, and the scientists now report their findings in <em><a class="content-link css-29oowu" href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31208-3/fulltext" target="_blank" rel="noopener noreferrer">The Lancet</a></em>.</p>
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<p class="standout--body"><span class="syndication-blacklist"><em>Stay informed with <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/live-updates-coronavirus-covid-19">live updates</a> on the current COVID-19 outbreak and visit our <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/coronavirus">coronavirus hub</a> for more advice on prevention and treatment.</em></span></p>
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<p>Thus far, the team is satisfied that the vaccine they are testing is mostly safe and holds the promise of effectiveness.</p>
<p>“These results represent an important milestone,” says lead researcher Prof. Wei Chen, from the Beijing Institute of Biotechnology in Beijing.</p>
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<div><a name="What-type-of-vaccine-is-it?"></a>What type of vaccine is it?</div>
<p>The vaccine in this clinical trial is called the “adenovirus type 5 vectored COVID-19 (Ad5-nCoV) vaccine.”</p>
<p>The vaccine uses an adenovirus — a common virus — that is no longer able to replicate or infect — as the “base” to which spike proteins specific to SARS-CoV-2 are attached.</p>
<p>Spike proteins are proteins present on the surface of viruses, which “help” the virus to infect healthy cells and spread further.</p>
<p><strong>By using an inactivated virus that features the SARS-CoV-2-specific spike protein, the vaccine’s purpose is to “teach” the human immune system to recognize the presence of SARS-CoV-2 and fight the virus.</strong></p>
<p>In phase 1, the researchers recruited 108 participants, of whom 51% were male and 49% female, with a mean age of 36.3 years.</p>
<p>The researchers split the participants into three equal groups to test three dosages of the vaccines: a low dose, a middle dose, and a high dose.</p>
<p>This trial was not randomized, and it was open-label, meaning that the researchers knew what they were administering, and the participants knew what they were receiving.</p>
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<p>The researchers collected and assessed blood samples from the participants regularly after the vaccinations. They also kept track of any emerging symptoms the participants might experience.</p>
<p><strong>At the 28-day mark post vaccination, the results indicated that the participants tolerated the experimental vaccine well, and, while many volunteers did have adverse reactions, these were not serious and did not last long.</strong></p>
<p>Of the participants who received a low dose of the vaccine, 30 (83%) reported at least one adverse reaction within 7 days from inoculation. The same proportion who received the middle dose reported adverse reactions within the same time frame.</p>
<p>Of those who received a high dose of the vaccine, 27 (75%) reported at least one adverse reaction within a week of vaccination.</p>
<p>The researchers note that the most common reactions were pain where they had received the injection (58 participants), <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/168266">fever</a> (50 participants), a sense of <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/248002">fatigue</a> (47 participants), <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/73936">headaches</a> (42 participants), and muscle pain (18 participants).</p>
<p>Only one participant — who received a high dose of the vaccine — experienced “severe fever […] with axillary temperature greater than 38.5 [degrees Celsius],” as well as severe fatigue, shortness of breath, and muscle pain. These symptoms subsided within 48 hours.</p>
<p>Two participants who received a low dose of the vaccine, two who received a middle dose, and five who had a high dose reported episodes of severe fever, too, but none of the other symptoms.</p>
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<div><a name="Is-it-likely-to-be-effective?"></a>Is it likely to be effective?</div>
<p>While this phase 1 clinical trial did not test for effectiveness by analyzing blood samples, the researchers were able to see if the vaccine had triggered an immune system reaction, a preliminary indicator that the vaccine is doing its job.</p>
<p>The researchers report that 14 days after the inoculation, all the participants, regardless of which dose they had, saw a rise in binding antibodies, molecules that “recognize” and attach to the virus, though they do not fight it.</p>
<p>Some of the participants, however, also presented neutralizing antibodies — or ones that do fight the virus — at 14 days after inoculation.</p>
<p>Specifically, 10 of the participants who had received low doses of the vaccine, 11 on a medium dose, and 15 of those who had high doses had a fourfold increase in neutralizing antibodies against SARS-CoV-2.</p>
<p>However, a rise in neutralizing antibodies “peaked” at 28 days post-vaccination. Eighteen of the participants on the low dose group, 18 of those in the middle dose group, and 27 of those from the high dose group presented neutralizing antibodies at that point.</p>
<p>But the researchers were most interested in whether or not the experimental vaccine would quickly induce the key immune cells known as T cells to respond.</p>
<p><strong>“The trial demonstrates that a single dose of the new [Ad5-nCoV] vaccine produces virus-specific antibodies and T cells in 14 days, making it a potential candidate for further investigation,” notes Prof. Chen.</strong></p>
<p>The researchers found activity from two types of T cells — CD4+ and CD8+ — both at 14 days and at 28 days after vaccination, in participants from all dose groups.</p>
<p>Those who received a high dose of the experimental vaccine had a higher expression of cytokines (special proteins) that both types of T cells secrete than those in the low and middle dose groups.</p>
<p>“However,” Prof. Chen warns, “these results should be interpreted cautiously.”</p>
<blockquote class="css-34gtoi"><p>“The challenges in the development of a COVD-19 vaccine are unprecedented, and the ability to trigger these immune responses does not necessarily indicate that the vaccine will protect humans from COVID-19. This result shows a promising vision for the development of COVID-19 vaccines, but we are still a long way from this vaccine being available to all.”<br />
– Prof. Wei Chen</p></blockquote>
<p>Going forward, the researchers have started phase 2 of the clinical trial, which aims to replicate the current results and find out whether participants experience any adverse effects at 6 months after inoculation.</p>
<p>Moreover, the team aims to recruit participants aged 60 years and over for phase 2 of this trial to find out whether the vaccine can protect the <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/the-impact-of-the-covid-19-pandemic-on-older-adults">demographic with a higher risk</a> of developing COVID-19, the disease that SARS-CoV-2 causes.</p>
<p>Link: <a href="https://www.medicalnewstoday.com/articles/first-human-trial-of-sars-cov-2-vaccine-initial-results-in#Is-it-likely-to-be-effective?">https://www.medicalnewstoday.com/articles/first-human-trial-of-sars-cov-2-vaccine-initial-results-in#Is-it-likely-to-be-effective?</a></p>
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<p>The post <a href="https://ambatechllc.com/first-human-trial-of-sars-cov-2-vaccine-initial-results-in/">First human trial of SARS-CoV-2 vaccine: Initial results in</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
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		<post-id xmlns="com-wordpress:feed-additions:1">2653</post-id>	</item>
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		<title>How to breathe properly for better health</title>
		<link>https://ambatechllc.com/how-to-breathe-properly-for-better-health/</link>
		
		<dc:creator><![CDATA[ambalsoft]]></dc:creator>
		<pubDate>Thu, 28 May 2020 17:33:11 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<guid isPermaLink="false">http://www.hdendoscopysoftware.com/?p=2651</guid>

					<description><![CDATA[<p>How to breathe properly for better health Breathing is usually an unconscious process. However, there are some optimal ways to breathe. This article looks at what happens inside a person’s body when they breathe. It also provides some tips and exercises for improving breathing efficiency. These are suitable for people with respiratory conditions and those [...]</p>
<p>The post <a href="https://ambatechllc.com/how-to-breathe-properly-for-better-health/">How to breathe properly for better health</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
]]></description>
										<content:encoded><![CDATA[<h1>How to breathe properly for better health</h1>
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<p class="css-dmtxcr">Breathing is usually an unconscious process. However, there are some optimal ways to breathe.</p>
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<p>This article looks at what happens inside a person’s body when they breathe.</p>
<p>It also provides some tips and exercises for improving breathing efficiency. These are suitable for people with respiratory conditions and those without them.</p>
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<div><a name="breathing-process"></a>What happens when a person breathes?</div>
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<figure class="css-yhe8zq"><span class="css-rwmw5v"><span class="css-mjp0j9"><picture class="css-16pk1is"><source srcset="//i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/04/GettyImages-1143696652_header-1024x575.jpg?w=1575 750w" media="(min-width: 1190px)" /><source srcset="//i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/04/GettyImages-1143696652_header-1024x575.jpg?w=1575 750w" media="(min-width: 990px)" /><source srcset="//i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/04/GettyImages-1143696652_header-1024x575.jpg?w=1845 879w" media="(min-width: 768px)" /><img decoding="async" class="css-1lwg88w" src="https://i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/04/GettyImages-1143696652_header-1024x575.jpg?w=1155&amp;h=1528" alt="a woman taking a deep breath as she shows how to breathe properly" /></picture></span></span><figcaption class="css-1h1noa3">Breathing through the nose may make the lungs work more efficiently.</figcaption></figure>
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<p>Breathing, or respiration, is a complex process of air exchange that involves the following parts of the body:</p>
<ul>
<li><strong>The lungs:</strong> These are a pair of spongy organs that sit on either side of the chest. The lungs expand when a person breathes in and contract when they breathe out. Each lung is surrounded by a thin membrane called the pleura, which protects the lung and allows it to slide back and forth during breathing.</li>
<li><strong>The diaphragm:</strong> This is a thin muscle that sits beneath the lungs and above the abdominal cavity. Its up-and-down movement helps the lungs contract and expand.</li>
<li><strong>The intercostal muscles:</strong> These are muscles that run between the ribs. They assist breathing by helping the chest cavity expand and contract.</li>
</ul>
<p>The lungs, diaphragm, and intercostal muscles work together to allow a person to breathe.</p>
<p>To breathe in, the diaphragm contracts and moves downward. This increases the space in the chest cavity, allowing the lungs to expand and fill with air.</p>
<p>To breathe out, the diaphragm relaxes, reducing the space in the chest cavity. This causes the lungs to deflate and let out the air.</p>
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<div><a name="correct-breathing"></a>What is the correct way to breathe?</div>
<p>Although breathing is a natural process, some people may be surprised to learn that there is a right and a wrong way to breathe.</p>
<p>The <a class="content-link css-29oowu" href="https://www.lung.org/blog/you-might-be-breathing-wrong" target="_blank" rel="noopener noreferrer">American Lung Association (ALA)</a> provide the following advice on how to breathe correctly.</p>
<h3>Use the nose</h3>
<p>Breathing through the nose can slow the breath and make the lungs work more efficiently. It also facilitates the intake of nitric oxide, which helps with oxygen transportation throughout the body.</p>
<p>Breathing through the nose also allows the nostrils to:</p>
<ul>
<li>filter toxins and allergens from the air, thereby preventing them from entering the body</li>
<li>warm air that is too cold</li>
<li>humidify air that is too dry</li>
</ul>
<p>However, breathing through the mouth is sometimes necessary if a person is exercising or has <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/323834">sinus congestion</a>.</p>
<h3>Use the belly</h3>
<p>The most efficient way to breathe is by bringing the air down toward the belly. As the diaphragm contracts, the belly expands to fill the lungs with air.</p>
<p>“Belly breathing” is efficient because it pulls the lungs downward, creating negative pressure inside the chest. This brings air into the lungs.</p>
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<h4 id="google_ads_iframe_/4788/mnt/otherrespiratory/DLB2_0__container__">Tips for healthy breathing and lungs</h4>
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<p>The following tips can help support breathing and maintain lung health.</p>
<h3>Do not overthink it</h3>
<p>Although it is useful to know how to breathe correctly, it is important not to overthink breathing. In some people, this could lead to <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/323454">anxiety</a> and shortness of breath.</p>
<p>People should remember that normal breathing is a carefully regulated process that does not require conscious thought.</p>
<p>Together, the lungs and kidneys keep the blood’s pH within a narrow range to allow the body to function properly. Receptors in the body monitor blood pH and oxygen levels. These receptors send signals to the brain, which, in turn, sends nerve impulses that tell the body how often to breathe, and how deeply.</p>
<h3>Maintain a healthful lifestyle</h3>
<p>People can improve their breathing by maintaining a healthful lifestyle. Try:</p>
<ul>
<li><strong>Exercising regularly:</strong> Getting regular aerobic exercise helps improve lung capacity, which is the amount of oxygen a person can take in with each breath.</li>
<li><strong>Avoiding large meals:</strong> Eating large meals can cause <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/321869">abdominal bloating</a>. When the abdomen is bloated, it can press against the diaphragm, preventing it from efficiently moving up and down. This can lead to shortness of breath. People who are prone to bloating should opt for smaller, more frequent meals.</li>
<li><strong>Maintaining a moderate weight:</strong> Having overweight increases a person’s risk of experiencing breathing difficulties such as <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/178633">obstructive sleep apnea</a>. People can reduce this risk by maintaining a moderate weight.</li>
<li><strong>Quitting smoking:</strong> The lungs contain tiny air sacs called alveoli, which are responsible for exchanging oxygen and carbon dioxide between the lungs and capillary blood vessels. <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/10566">Smoking </a>damages the alveoli, making them less efficient.</li>
</ul>
<h3>Monitor the air quality</h3>
<p>People can monitor the air quality in areas where they live and work. They can use this information to limit their exposure to pollutants and allergens that affect breathing.</p>
<p>When possible, people should avoid areas of heavy traffic and always <a class="content-link css-29oowu" href="http://www.stateoftheair.org/" target="_blank" rel="noopener noreferrer">check the air quality</a> before they exercise outdoors.</p>
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<div><a name="respiratory-conditions"></a>Tips for people with respiratory conditions</div>
<p>People who have respiratory conditions such as <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/323523">asthma</a> or <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/141287">chronic obstructive pulmonary disease (COPD)</a> can take further precautions to protect their breathing and lung health.</p>
<p>For example, they can try:</p>
<ul>
<li><strong>Staying hydrated:</strong> Drinking plenty of water helps the throat and mouth add humidity to the air a person breathes in. Humid air is less likely to irritate the airways.</li>
<li><strong>Eliminating sources of indoor air pollution:</strong> People should ensure that their living and working environments are clean, well-ventilated, and free of mold. This will help prevent irritation of the airways.</li>
<li><strong>Using protective equipment at work:</strong> Some people may work in an environment where they have exposure to dust, chemicals, or vapors. These people should wear a mask to avoid inhaling these irritants.</li>
<li><strong>Getting the flu shot or pneumonia vaccine: </strong>These vaccinations help protect people with respiratory conditions.</li>
<li><strong>Trying relaxation exercises:</strong> Breathing exercises and other relaxation techniques can help a person stay calm and prevent them from <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/323607">hyperventilating</a>.</li>
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<p class="css-nz9v2z">Breathing exercises</p>
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<p>Breathing exercises help slow down a person’s breathing pattern and improve lung efficiency. They are particularly beneficial for people with asthma, COPD, and other conditions that cause shortness of breath. They can also help calm a person who is feeling anxious.</p>
<p>However, people should try to begin practicing breathing exercises when their breathing is normal — not while they are experiencing shortness of breath.</p>
<p>The <a class="content-link css-29oowu" href="https://www.lung.org/lung-health-diseases/wellness/breathing-exercises" target="_blank" rel="noopener noreferrer">ALA</a> recommend two different breathing techniques for people to try: pursed lip breathing and diaphragmatic (belly) breathing.</p>
<p>Ideally, people should practice both exercises for <a class="content-link css-29oowu" href="https://www.lung.org/lung-health-diseases/wellness/breathing-exercises" target="_blank" rel="noopener noreferrer">5–10 minutes every day</a>. Some people may need to build up to this duration gradually.</p>
<h3>Pursed lip breathing steps</h3>
<ol>
<li>Sit down in a chair and relax the neck and shoulder muscles.</li>
<li>Breathe in slowly through the nose while keeping the mouth closed. Inhale for 2 seconds.</li>
<li>Pucker or purse the lips, as if whistling or blowing out a candle. Exhale slowly for 4 seconds.</li>
<li>Repeat the above steps.</li>
</ol>
<h3>Diaphragmatic breathing steps</h3>
<p>A person can perform the following steps while lying down or sitting up straight in a chair.</p>
<ol>
<li>Place both hands on the abdomen, feeling the rise and fall of each breath.</li>
<li>Close the mouth and take a slow breath in through the nose, while feeling the abdomen rise and inflate like a balloon.</li>
<li>Breathe out slowly through pursed lips, as if blowing bubbles, with each expiratory breath taking about two to three times as long as each inhalation.</li>
<li>Repeat these steps for 5–10 minutes. Keep the hands on the abdomen to help improve awareness of the correct breathing technique.</li>
</ol>
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<div id="google_ads_iframe_/4788/mnt/otherrespiratory/DLB3_0__container__">Summary</div>
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<p>Using correct breathing techniques can help improve a person’s lung efficiency. It can also help alleviate <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/145855">stress</a> and anxiety. Correct breathing is therefore beneficial for both physical and <a class="content-link css-29oowu" href="https://www.medicalnewstoday.com/articles/154543">mental health</a>.</p>
<p>Taking a few minutes each day to practice breathing techniques can help people form better breathing habits. It can also help people with respiratory conditions manage periods of shortness of breath.</p>
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<p>Link: <a href="https://www.medicalnewstoday.com/articles/how-to-breathe-properly#summary">https://www.medicalnewstoday.com/articles/how-to-breathe-properly#summary</a></p>
<p>The post <a href="https://ambatechllc.com/how-to-breathe-properly-for-better-health/">How to breathe properly for better health</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
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		<title>Prevalence of advanced polyps similar at ages 45-49, 50-54 years</title>
		<link>https://ambatechllc.com/prevalence-of-advanced-polyps-similar-at-ages-45-49-50-54-years/</link>
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		<dc:creator><![CDATA[ambalsoft]]></dc:creator>
		<pubDate>Thu, 28 May 2020 17:28:30 +0000</pubDate>
				<category><![CDATA[Endoscopy]]></category>
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					<description><![CDATA[<p>Prevalence of advanced polyps similar at ages 45-49, 50-54 years SAN ANTONIO — The increased prevalence of advanced adenoma and clinically significant serrated polyps was similar among age groups on both sides of age 50 years, suggesting that screening at 45 years optimizes colorectal cancer prevention, according to study results presented at the American College of [...]</p>
<p>The post <a href="https://ambatechllc.com/prevalence-of-advanced-polyps-similar-at-ages-45-49-50-54-years/">Prevalence of advanced polyps similar at ages 45-49, 50-54 years</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
]]></description>
										<content:encoded><![CDATA[<h2>Prevalence of advanced polyps similar at ages 45-49, 50-54 years</h2>
<p>SAN ANTONIO — The increased prevalence of advanced adenoma and clinically significant serrated polyps was similar among age groups on both sides of age 50 years, suggesting that screening at 45 years optimizes <a href="https://www.healio.com/hematology-oncology/gastrointestinal-cancer/news/online/%7B54fe0eab-74fa-4256-a2ce-9f22176110a3%7D/intervention-improves-colorectal-cancer-screening-in-rural-areas" target="_blank" rel="noopener noreferrer">colorectal cancer prevention</a>, according to study results presented at the American College of Gastroenterology Annual Meeting.</p>
<p><strong>Lynn F. </strong><strong>Butterly</strong><strong>, MD,</strong> of Dartmouth-Hitchcock Medical Center, said that while the incidence of CRC among patients older than 50 years has decreased significantly, it has increased by more than 50% among patients <a href="https://www.healio.com/hematology-oncology/gastrointestinal-cancer/news/online/%7B71c59868-0018-438f-bd56-31b7339c0857%7D/early-onset-colorectal-cancer-clinically-molecularly-distinct-from-late-onset-disease" target="_blank" rel="noopener noreferrer">younger than 50</a> years.</p>
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<h5 class="section-head">SEE ALSO</h5>
<ul class="module list-unstyled link-grp">
<li><a href="https://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/print/healio-gastroenterology/%7B7754ff2e-d7b8-4c08-ada9-a62c3844c2fc%7D/ibs-transitioning-from-a-syndrome-to-a-disease">IBS: Transitioning from a Syndrome to a Disease</a></li>
<li><a href="https://www.healio.com/gastroenterology/motility/news/print/healio-gastroenterology/%7B825f9a5e-21ad-4df3-9fe1-d167c42c2a4a%7D/sleep-quality-improvement-a-tremendous-opportunity-in-treating-gi-conditions">Sleep Quality Improvement a ‘Tremendous Opportunity’ in Treating GI Conditions</a></li>
<li><a href="https://www.healio.com/hematology-oncology/gastrointestinal-cancer/news/print/hemonc-today/%7Be064718a-f71e-4171-9e87-c812c39a81c7%7D/strategic-menu-of-noninvasive-options-needed-to-boost-colorectal-cancer-screening-rates">‘Strategic menu’ of noninvasive options needed to boost colorectal cancer screening rates</a></li>
</ul>
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<p>“In May of 2018, the [American Cancer Society] made a qualifying recommendation to lower the age to start colorectal cancer screening to 45 from 50, where it is now,” she said in her presentation. “The authors note that the qualified recommendation indicates that there is clear evidence of benefit, just less certainty about the balance of benefits and harms and patient preferences due to lack of hard available data.”</p>
<p>Researchers analyzed data from the New Hampshire Colonoscopy Registry to explore age-related prevalence of advanced findings among an average risk screening cohort comprising individuals aged younger than 50 years compared with older patients. To ensure they had the appropriate average risk population, investigators excluded higher-risk indications like gastrointestinal bleeding, occult blood, iron deficiency anemia and abnormal imaging. They also excluded surveillance exams, individuals with family history of CRC, incomplete exams and exams with poor bowel preparation. Patients with symptoms like abdominal pain and constipation were included as an “average risk equivalent” cohort.</p>
<p>Among their study population (n = 43,600), Butterly and colleagues found that advanced adenoma prevalence increased significantly at age 40 years, and the prevalence at ages 45 to 49 was similar to that found in ages 50 to 55 (3.7% vs. 3.6%).</p>
<p>Prevalence of advanced adenomas was 4.4% at screening, 3.2% in the included diagnoses and 5.8% in the excluded diagnoses, which Butterly said supported their assumptions about indication. Additionally, low-risk symptoms were not associated with an increased risk (OR = 1.03; 95% CI, 0.84–1.13).</p>
<p>“The clinical implications of our findings are that our findings support the recommendation to begin average risk colorectal cancer screening at 45,” Butterly said. “Clearly, future research will need to address risk stratification within that 45- to 49-year-old group, as well as effectiveness and cost effectiveness of the various screening options.” – <em>by Alex Young</em></p>
<p><strong>Reference:</strong></p>
<p>Butterly LF, et al. Abstract 25. Presented at: American College of Gastroenterology Annual Meeting; Oct. 25-30, 2019; San Antonio.</p>
<p>Link: <a href="https://www.healio.com/gastroenterology/oncology/news/online/%7B45c75cbd-369a-4dce-951c-8c8d05a45f30%7D/prevalence-of-advanced-polyps-similar-at-ages-45-49-50-54-years">https://www.healio.com/gastroenterology/oncology/news/online/%7B45c75cbd-369a-4dce-951c-8c8d05a45f30%7D/prevalence-of-advanced-polyps-similar-at-ages-45-49-50-54-years</a></p>
<p>The post <a href="https://ambatechllc.com/prevalence-of-advanced-polyps-similar-at-ages-45-49-50-54-years/">Prevalence of advanced polyps similar at ages 45-49, 50-54 years</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
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		<post-id xmlns="com-wordpress:feed-additions:1">2649</post-id>	</item>
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		<title>Aspirin doubles risk for upper GI bleeding events in older adults</title>
		<link>https://ambatechllc.com/gi_one/</link>
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		<dc:creator><![CDATA[ambalsoft]]></dc:creator>
		<pubDate>Mon, 19 Nov 2018 17:08:31 +0000</pubDate>
				<category><![CDATA[Endoscopy]]></category>
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					<description><![CDATA[<p>Aspirin doubles risk for upper GI bleeding events in older adults Andrew T. Chan Aspirin almost doubles the risk for serious upper gastrointestinal bleeding in older people and can further increase with age, smoking, chronic kidney disease and NSAIDs, according to data from Digestive Disease Week. “This study confirms that among older adults, low dose [...]</p>
<p>The post <a href="https://ambatechllc.com/gi_one/">Aspirin doubles risk for upper GI bleeding events in older adults</a> appeared first on <a href="https://ambatechllc.com">AMBATECH LLC</a>.</p>
]]></description>
										<content:encoded><![CDATA[<h1>Aspirin doubles risk for upper GI bleeding events in older adults</h1>
<div class="mug left"><img decoding="async" src="https://i0.wp.com/m4.healio.com/~/media/slack-news/gastroenterology/mugs/c/chan_andrew_2020.jpg?resize=80%2C106&#038;ssl=1" alt="Andrew Chan headshot" width="80" height="106" data-recalc-dims="1" /></p>
<div class="name"><strong>Andrew T. Chan<br />
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<p>Aspirin almost doubles the risk for serious upper gastrointestinal bleeding in older people and can further increase with age, smoking, chronic kidney disease and NSAIDs, according to data from Digestive Disease Week.</p>
<p>“This study confirms that among older adults, low dose aspirin is associated with an increased risk of gastrointestinal bleeding with the risk highest among those who smoke and have high blood pressure or kidney disease,” <strong>Andrew</strong><strong> T.</strong><strong> Chan, M</strong><strong>D,</strong> chief, clinical and translational epidemiology unit director of cancer epidemiology at Massachusetts General Cancer Center, told <em>Healio Gastroenterology.</em></p>
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<li><a href="https://www.healio.com/news/online/%7B5b33a402-9f4a-4652-bef3-c0d3132b2d72%7D/cvd-cancer-depression-influence-kidney-disease-risk-in-diabetes">CVD, cancer, depression influence kidney disease risk in diabetes</a></li>
<li><a href="https://www.healio.com/news/online/%7B3ff082b8-46e3-452e-b49b-65be0d3bf0b6%7D/patients-with-gout-have-30-higher-risk-for-chronic-kidney-disease">Patients with gout have 30% higher risk for chronic kidney disease</a></li>
</ul>
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<p>Chan and colleagues assessed data on 19,114 patients from Aspree, an aspirin primary prevention trial. In the trial, 9,525 patients were randomly assigned to receive aspirin while 9,589 received placebo. Annually, investigators collected baseline clinical characteristics and a physician panel standardized and adjudicated GI bleeding events. The incidence of upper and lower GI bleeding was calculated. Then, predictors were identified with Cox regression analyses and the absolute risk for bleeding based on age and risk factors was modeled.</p>
<p>Of the 264 reported serious GI bleeding events, 137 were upper GI events (aspirin group n = 89, placebo group n = 48; HR = 1.87; 95% CI, 1.32-2.66) and 127 were lower GI events (aspirin group n = 73, placebo group n = 54; HR = 1.36; 95% CI, 0.96-1.94). Age, smoking, chronic kidney disease and NSAID use were risk factors for upper GI bleeding while age, smoking and hypertension were risk factors for lower GI bleeding, according to multivariate analyses. Proton pump inhibitor use was not linked to reduced bleeding events.</p>
<p>Chan and colleagues reported that the absolute, 5-year serious bleeding risk was 0.2% for 70-year-olds and 0.4% if patients were on aspirin, and up to 5.5% for 80-year-olds on aspirin with significant risk factors.</p>
<p>“Because this study was a rigorously performed randomized controlled trial, it provides more accurate estimates of the absolute risk of bleeding among individuals who initiate aspirin at an older age,” Chan said. “This will be useful for further studies to appropriately weigh the risks and benefits of low dose aspirin treatment.” – <em>by Monica Jaramillo</em></p>
<p><strong>Reference:</strong> Mahady SE, et al. Abstract 337. Presented at: Digestive Disease Week; May 2-5, 2020; Chicago (meeting canceled).</p>
<p>Link: <a href="https://www.healio.com/gastroenterology/stomach-duodenum/news/online/%7Bb1fcb4de-18b0-4910-a75d-c8f9bf6ec63b%7D/aspirin-doubles-risk-for-upper-gi-bleeding-events-in-older-adults">https://www.healio.com/gastroenterology/stomach-duodenum/news/online/%7Bb1fcb4de-18b0-4910-a75d-c8f9bf6ec63b%7D/aspirin-doubles-risk-for-upper-gi-bleeding-events-in-older-adults </a></p>
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